BIOMEDICINE – INFECTIOUS DISEASE DRUGS: Antifungals
ACTION: Damages fungal cells that causes increased cell permeability, which allows cell contents to leak.
INDICATIONS: Antifungal prophylaxis in patients undergoing bone marrow transplant; Systemic candidiasis; Cryptococcal meningitis.
SIDE EFFECTS:
CNS: Chills, dizziness, drowsiness, fever, headache, seizures
CV: Prolonged QT interval, torsades de pointes
GI: Abdominal pain, anorexia, constipation, diarrhea, hepatic failure, nausea, vomiting
HEME: Agranulocytosis, leukopenia, thrombocytopenia
SKIN: Exfoliative dermatitis, photosensitivity, pruritus, rash
Other: Anaphylaxis, angioedema
PRECAUTIONS:
Contraindications: Concomitant administration of QT-prolonging medications.
Cautions: Hepatic/renal impairment, hypersensitivity to other triazoles (e.g., itraconazole, terconazole), imidazoles (e.g., butoconazole, ketoconazole).
INTERACTIONS:
DRUG: increases cyclosporine, sirolimus, tacrolimus concentrations. May increase concentration/effects of oral anti- diabetic medication. Isoniazid, rifampin may increase drug metabolism. May decrease metabolism of phenytoin, warfarin.
HERBAL: None significant.
FOOD: None known.
LAB VALUES: May increase serum alkaline phosphatase, bilirubin, ALT, AST.
(Diflucan)
TCM – Chapter
Enters:
Temperature:
Taste:
ACTIONS:
INDICATIONS:
Tongue:
Pulse:
RATIONALE:
CAUTION:
NOTE:
MODIFICATIONS: